Oncomine TCR Beta-SR Assay
Interrrogate the tumor microenvironment with an Ion Torrent short-read NGS assay
The identification of T-cell clones in tumors and the measurement of clonal expansion is important to characterize tumors, design cancer vaccines, and assess the utility for researching minimal residual disease (MRD). The CD3 region on the beta (β) chain of the T-cell receptor is most responsible for antigen recognition.
The sequence coding for the CDR3 region is extremely diverse and is unique for every T-cell clonotype. Hence, in immune repertoire sequencing, the CDR3 sequences are used to identify a T-cell clonotype. The Oncomine TCR Beta-SR Assay targets the CDR3 region, enabling such investigations.